Sort of tangential: I used to be able to tell episodes of depression were setting in because I'd stop brushing my teeth. It was the clearest indicator I can recall.

I'd then brush my teeth hoping it would cure the depression. It clearly worked, because I'm no longer depressed. It just took a few years to kick in.

Always remember to brush your teeth.

Counter-anecdote, I did the same, got Burt's Bees with novamin when they still sold it (discontinued), then switched back to Crest. I prefer the Crest. No cavities either way, but tooth sensitivity and clean feeling differences. A tooth chip I wondered might remineralize, i.e. grow back or fill in or something, had no change.

My guess is the SLS detergent, present in Crest and not in Burt's, is the more significant factor.

Any idea about mHAP (hydroxi apatite)

Do you eat much sugar? Soda or juice? These things make a huge difference. So does age. Young people get cavities easier than somewhat older people.

I think it's just poorly written. If you go to the source[1] the trial period was planned from September 2024 to August 2025, and the submission says people are "undergoing" a trial. Perhaps it got delayed, or, more likely IMHO, the trial period is over and they're studying the data so haven't made reached a conclusion yet.

[1]: https://www.kitano-hp.or.jp/info/20240503

It’s a phase 1 clinical trial designed only to assess safety and determine the appropriate dosage. Future trials will focus on efficacy.

I personally regrew my teeth since I was a child. Granted, once.

> At least unique enough to use dental records to identify bodies.

Yes but in comparative dental analysis they use ante-mortem dental records to compare with post-mortem remains. It's not like DNA where you can record it once and then use that to match samples decades later in a database. In order to have a high confidence in a match, recent x-rays and records of dental work like fillings, crowns, etc. work best.

And no it is not expected. It's one of the primary challenges with bringing these kinds of drugs to market, as hyperdontia is already relatively common among humans (I had an incisor growing at the roof of my mouth an inch behind my row of teeth). Most successful applications of these tooth regrowth drugs tend to place them near the root of missing teeth hoping that the cellular growth signaling mechanisms are still working.

Teeth wear quite a bit too, I wonder will new ones have to be pared down to fit.

Let me introduce you to the teratoma:

https://en.wikipedia.org/wiki/Teratoma

a haircut made of teeth though, hmm

We all shoult fear the vagina dentata.

https://www.bbc.com/news/articles/cn09kwrg57do

Mix hair in your toothpaste

https://www.bbc.com/news/articles/c9qy0w27213o

Phase 2 trials on PP405 just completed. They’ll probably begin phase 3 trials sometime next year if you’re looking to enroll.

https://clinicaltrials.gov/study/NCT06393452

I am hoping for advancements in cartilage growth. I underwent microfracture surgery in my knee and will eventually need a replacement unless we make progress in this field. I would prefer to avoid knee replacement if possible because I enjoy being active. I am hopeful we’re getting close.

$4k and a trip to Turkey. I did it last tear and can recommend :)

My meniscus would like a word.

And limbs.

finasteride + minoxidil

What changes in your subjective sensation of your teeth with K2?

This guy's been downvoted badly but he's right - vitamin k2 make your teeth into "superteeth".

I started K2 about 10 years ago. Next dental checkup (about a year too late) the dental tech said my teeth appeared recently-cleaned. This has continued since then. No cavities, little cleaning required other than regular brushing, flossing and taking k2.

Why mk4 over mk7?