Good news is that Pyodide[1] is still actively maintained and developed!

"The honest picture is that PyScript remained a niche." Running Python directly in the browser is great and gives lots of opportunities. However in the AI era generating sloppy for browser apps seems the way forward...

[1] Pyodide is a port of CPython to WebAssembly/Emscripten. https://pyodide.org/

there is also:

* emscripten-forge [1] which is a conda-distribution for emscripten-wasm32 / emscripten-wasm64

* jupyterlite [2] which runs jupyter notebooks in the browser and has kernels for python,r-lang, sqlite,cpp,octave, javascript and many more.

* notebook.link [3] which is a high level platform around jupyterlite that allows to share notebooks.

Disclaime: I am the main author of emscripten-forge, I am a contributor to jupyterlite and work for the company behind notbook.link

[1] https://emscripten-forge.org/

[2] https://jupyterlite.readthedocs.io/en/stable/

[3] https://notebook.link/