Terr_
11 hours ago
> Sunburn is triggered when your DNA is damaged from light absorption [...] This interferes with protein synthesis and wreaks havoc in your body over time
Not a skin-scientist, but this seems misleading: Sunburn is not caused by some bad DNA floating around, nor damaged cells making making mistakes or pumping out wrong proteins to inflame their neighbors.
Instead, your cells have techniques to measure a variety of risk factors and signals (which does include DNA-molecule weirdness [0]) and when things get too risky the well-behaved ones will self-destruct, to avoid the chance of turning into a cancer.
So the sunburn you see and feel is instead due to cells signalling "something damaged me and I can't be trusted, I'm shutting down, recycle me" to your immune-system, plus the attendant bustle of hazmat-cleanup and increased security-sweeps for cancer-leftovers and other potential causes of the damage.
skullone
11 hours ago
This whole article shouldn't even exist, and should just point to wikipedia or mayo clinic.
somat
5 hours ago
Another interesting way to consider it is that a sunburn is a really mild case of radiation sickness.
Or the other way radiation sickness is the deepest worst sunburn you have ever had.
rogerrogerr
5 hours ago
Our immune system is _so cool_. Seems like every week I learn something new about it.
Terr_
an hour ago
As a book recommendation: Immune - Journey Into the Mysterious System That Keeps You Alive by Dettmer, Philipp.
Or for something a bit more immediate and casual, the Kurzgesagt playlist of immune-system videos. [0]
[0] https://www.youtube.com/show/VLPLFs4vir_WsTyS2cy4vj4obl5igqC...
EA-3167
9 hours ago
DNA is the instruction set for protein synthesis. If your DNA is damaged beyond repair that's an issue, and sure apoptosis is the usual result and not cancer. At the same time however when cells die either from the direct impact of DNA damage or apoptosis they both stop working and spill their contents into the area... including signalling molecules that promote inflammation.
The sunburn you feel isn't a distress signal from cells warning that they can't be trusted, it's tissue death and an inflammatory reaction triggered by a cytokine response.