drugs have been making people feel good (and messing with their sense of motivation to behave responsibly) regardless of society's state

Supposedly there was a time when drinking beer was often safer than drinking water from available sources, including for children. I guess there are levels

I know what you meant. But the words you used apply to my reply too. It's a reminder that any attempt at an objective definition of "drugs" includes alcohol and caffeine, and that there is a huge cultural component to "good drugs" and "bad drugs". In fact, coffee was considered one of the bad drugs by many cultures it when first introduced to them - including European culture.

> ... I completely lose the ability to be a good worker bee ...

Caffeine in Floral Nectar Enhances a Pollinator's Memory of Reward - https://www.science.org/doi/10.1126/science.1228806

> Caffeine improves memory in humans, millions of whom find that their daily dose enhances clarity, focus, and alertness. The human relationship with caffeine is relatively recent, however, and thus its impact on our brains is likely a by-product of its true ecological role. Caffeine occurs naturally in the floral nectar of Coffea and Citrus plants. Wright et al. (p. 1202; see the Perspective by Chittka and Peng) found that caffeine presented at naturalistic levels significantly improved the ability of bees to remember and locate a learned floral scent and potentiated the responses of neurons involved in olfactory learning and memory.

PBS Eons Why Does Caffeine Exist? (5:13 for the bit on bees) - https://www.youtube.com/watch?v=PzshAqowsyI

> In experiments on bees, researchers have found that once they've had a sip of caffeine-laced nectar, it boosts their memory, makes them preferentially revisit the plants, and even helps them pollinate faster and more efficiently. So, for plants, caffeine is a multi-purpose molecule with a lot of adaptive benefits. But, for us, it has one main benefit: it gets us through Monday morning. ...

Chesterton called it, quite fittingly, "The Puritan's opium".

> Many (perhaps most) drugs cause harm at the wrong dosage.

Not only drugs, almost everything is bad at the wrong dosage. Case in point: water.

Depending on your definition of poison of course, but at least for LSD and magic mushrooms, all that's known is a lower bound for their biological toxicity. For LSD IIRC it's somewhere in the 30mg (!) range, for mushrooms it's more than can comfortably fit a stomach. I'm afraid I don't have sources handy though.

That said, the state of mind must be so wild that "is it poisonous in this specific/usual sense" is probably not the right thing to discuss.

So for mold, low enough doses aren't poison? Can't you just say this about anything. If you have poison in a low enough dose it's not poison. So it means jsut about nothing to say alcohol isn't poisonous because you can have a small dose of it.

Alcohol requires an astronomical intake compared to most drugs, and I'd say the indiscriminate action and lack of any particular affinity is what makes it a poison as opposed to a drug. It is also generally assumed that alcohol is not exactly in the same category as drugs. ("drugs or alcohol" etc.)

One of the reasons this is such a long bow to draw is that, as you have absurdly reiterated and an earlier commenter posited, this is Lamarckism. If it is true, where are all the sapient reindeer and other animals that have consumed these substances as a species for as long or longer than we have existed?

Ok, but there are plenty of psychedelics that don't come from fungi.