mutagen
10 hours ago
This thesis appears to be related or the underlying research:
https://d.lib.msu.edu/etd/51312
Indicates 2mg and 5mg were given along with the placebo. While these are common dosages available in the US, these are higher dosages than recommended by at least some sleep experts. The thesis doesn't seem to differentiate between the dosages when evaluating cognitive processes.
Now I want to evaluate my sleep stack against morning cognition.
koliber
6 hours ago
I read a while back that our brains produce roughly 0.3 mg of melatonin when signaling us to go to sleep. When I occasionally do use melatonin I split a 1mg pill into half or thirds. I find that it works well enough to help me fall asleep. Wondering how the study would look if hwy used 1/2 mg doses.
mettamage
6 hours ago
Go to the Netherlands, to the Kruidvat (or Etos or something similar) and just buy a lifetime worth of supply of Melatonin. It's 0.1 mg.
I'm Dutch and live here. But my wife is American. If I ever happen to live in the US (chances are there in my lifetime). I'm going to employ this strategy.
I don't trust the US with this and the Netherlands has proven itself to me in this sense. There are probably many more European countries that do this well. I'm simply not changing a winning team.
But I'd love to hear from other people that believe they found a good melatonin supply in a country. I'm curious.
tedggh
2 hours ago
Drugs are regulated with the same care in the US, the problem is you are comparing a drug in Europe with a dietary supplement in the US. You can’t expect to grab a high quality of any dietary supplement from say Walmart. It’s the same in Europe. In the US there are labs making high quality dietary supplements, but you usually don’t find them at retail stores or even Amazon, so it needs a bit of research.
bityard
10 minutes ago
You seem to be beating around some kind of bush by intentionally neglecting to define your definition of "high quality" in this context. Are you saying that 1mg of melatonin from Walmart or Amazon do not actually contain 1mg of melatonin?
briHass
an hour ago
Walmart typically carries a large selection of supplements from the 'Nature Made' brand (yellow label), which tests/certifies most of their products through the independent 'U.S. Pharmacopeia (USP)'.
While that may not help with the arguments over the correct dosage, it at least means you can trust the ingredients and dosage on the label isn't a lie. A random mail order supplement or bulk powder seller on Amazon...not so much.
hattmall
2 hours ago
If they aren't sold in retail stores or Amazon how are they sold? Private websites?
Amazon requires random sampling confirmation for supplements from independent labs though, so anything officially listed in a supplement category should be reliable.
yalok
3 hours ago
One can get kids doses that are 0.5 or 0.25mg. Eg see this 0.25 product on Amazon - https://a.co/d/0j74eWFP
koliber
4 hours ago
I feel that the 1mg pill bottle that I have already is my lifetime supply, given the rate at which I use it.
mettamage
3 hours ago
I've been supplementing for almost 2 years. It still works.
I unfortunately need a lifetime supply. I almost take it every day. So 0.3 mg * 300 days * 100 years = 9 grams of melatonin.
I don't expect to live 100 years but it's handy to have a bit of an oversupply.
jack_pp
2 hours ago
I used to do this too, but I learned that will give you inconsistent dosage as the pills aren't guaranteed to have the active ingredient spread uniformly.
inejge
2 hours ago
If the pill has a score line, it's designed for halving (or quartering, if it has two.) Otherwise, no guarantees.
hinkley
8 hours ago
Long ago when I paid attention to this, the wisdom was to watch out because most melatonin pills are targeted to geriatric patients. Old folks need a significant boost to their melatonin to deal with eroding sleep quality, not a little hit of it. So as a 30 year old or younger you want a fraction of what grandad is taking.
HexPhantom
7 hours ago
You'd expect the standard OTC dose to be a sensible starting point, not potentially several times more than a younger person needs
gruturo
5 hours ago
For sleep aids this is often not the case. I'm in my early 50s and tried Doxylamine Succinate 2 years ago for the first time - an innocent Costco "Sleep Aid".
I was beyond groggy - quite nonfunctional - until the following afternoon and would not have trusted myself with operating a car even then.
hinkley
6 hours ago
You wouldn’t, if you remembered that medically speaking, younger people “needing” melatonin pills has been pretty fringe until very recently, and the number of young people who need it is still comparatively small.
You can find smaller pills. But you might have to try several chains or order online to get them.
sersi
2 hours ago
It's been the standard recommendation for dealing with jetlag in the last 15-20 years. And usually people who regularly experience jetlag due to repeated international professional trips are not elderly.
Angostura
3 hours ago
If they are targeted at older patients, I'd expect them to be a sensible starting point for older patients
glenngillen
3 hours ago
Last time I was in the US the lowest dose melatonin gummies I could find in a CVS were 1mg — kids gummies.
That's more than 3x the actual recommended dose for an average adult based on the research others have shared in this thread. So no, they're not starting from a sensible starting point.
hinkley
2 hours ago
Were they packaged as kid gummies or are you presuming that gummies = kids? Because that hasn’t been the case for a long time. Those vitamin D gummies I buy because I will take them instead of might take them consistently, are not child doses either. They’re marketing gummies to adults here.
siva7
3 hours ago
There is no such thing as "older people" dose.
Palomides
2 hours ago
it's sold in the US as a more or less unregulated supplement, so not surprising to me that the dosing is nonsense
ajb
6 hours ago
There is a rumour that the high doses are because the correct dose was under patent.
I can only find that in a comment here: https://slatestarcodex.com/2018/07/10/melatonin-much-more-th... but I could have sworn it was in the main article when I first read it. (If so that makes it less likely, because the author revises his articles for correctness)
That (albeit long) article is worth reading. For example, it explains that melatonin is a phase signal, so being saturated with too much melatonin actually makes the signal less clear (as well as potentially causing other issues).
budsniffer952
5 hours ago
That's not a "rumour", it's conspiracy theory. Because everything is a conspiracy theory now.
No, the dosage is not patented. It doesn't even make sense. How would it work? "Oh, 0.5mg is patented, so let's put 1mg in the tablets and never sell 0.5mg".
I can get all kinds of dosages from the pharmacy. However, most of what they stock is "too high", probably because there's very little research/wisdom/knowledge around the supplement.
budsniffer952
5 hours ago
I love that people have developed a "sleep stack" without ever even knowing if what they take is improving the effects of sleep.
bookofjoe
3 hours ago
"sleep stack" gets my vote for winner of the 2026 "How You Know You're On HN" award
satvikpendem
2 hours ago
It's common in the biohacking community especially on X. I've heard about it there much earlier and more frequently than I ever did here.
toilet
5 hours ago
People would rather get a wifi connected smart bed and track their sleep stats with a smart watch than put their phone away and read a book before bed
discreteevent
4 hours ago
"Americans have a special horror of giving up control, of letting things happen in their own way without interference. They would like to jump down into their stomachs and digest the food and shovel the shit out."
William Burroughs - Naked Lunch
fragmede
5 hours ago
To be fair, the 8sleep is pretty nice because it heats and cools you so you get better sleep, and you can still put your phone away if you have one.
hackable_sand
4 hours ago
Better sleep than what?
Humans have been sleeping for at least 400 years
huehehue
3 hours ago
I get what you're saying, but let's not pretend the modern world isn't meaningfully different. Artificial light is a big factor, yes. So are odd and constantly changing work hours from a world that now operates 24/7. So is the common expectation of monophasic sleep in general. So is travel and jet lag that we now have to endure, and dietary changes, and stimulants especially for folks who just don't even have 8 uninterrupted hours available for sleep. So are dramatic global temperature changes. The list goes on, and there is more data in this paper https://pmc.ncbi.nlm.nih.gov/articles/PMC11152632/
I can hardly blame anyone for wanting to "hack" or "optimize" their sleep. It seems more necessary now than it has ever been.
epihelix
2 hours ago
I suspect their point was that optimising sleep is relatively simple. Go to bed in a timely manner, keep your bedroom cool, use blackout blinds and sunrise lamps. Don't drink caffeine in the afternoon or evening. It's not rocket science.
avesi
2 hours ago
I know an obese individual who has one and I'm sure having a ventilated bed helps them sleep more comfortably.
hackable_sand
2 hours ago
Health concerns make sense
63stack
2 hours ago
Are you sceptical if people have slept before 1600, or what's with the "at least?"
hackable_sand
2 hours ago
Conservative estimate
bluefirebrand
an hour ago
I wonder what the actual sleep quality of people 400 years ago looked like
My guess would be "not great"
efficax
4 hours ago
at least!
entropie
4 hours ago
Which is total unrelated and therefore i dont know what you want to commit to the discussion.
sd9
4 hours ago
It’s not unrelated. Avoiding light before bed, seeing sunlight in the morning, and keeping a regular waketime, has a great impact on sleep.
bohaska
7 hours ago
Thanks for finding that!
I apologize for not reading the full study before submitting it on Hacker News and for the misleading headline on the frontpage given the context of the dosages used, I really should have noticed that the link only contained an abstract.
wincy
9 hours ago
I take 300mcg when I’m having a hard time getting to sleep or if I’ve had a lot of caffeine. Mostly because Scott Alexander told me to.
epihelix
2 hours ago
Would it not be easier to not drink so much caffeine late in the day? Unless you're jetlagged, there's not much evidence AFAIK that melatonin will induce sleep better than a placebo.
archagon
2 hours ago
Not OP, but I’ve had horrible sleep over the past year. I had taken melatonin a while back before stopping, so on a whim, I decided to bite off a bit of one of my old 5mg pills before sleep. Didn’t give it any second thought — didn’t even think it would do anything. But I slept like a baby for the first time in months. And it’s completely reproducible.
mutagen
9 hours ago
Yeah I'm in the 300 mcg camp, I take a time release formulation, try to take it early but often it isn't far off bedtime.
avarun
2 hours ago
Which specific product do you take? Do you have a link?
gleenn
8 hours ago
I end up biting a lot of pills to get around that dose. I definitely always felt groggy until I dialed down the dose to just right, and it works perfectly: I fall asleep far quicker and more assuredly, and I don't feel to groggy. I can't believe they sell pills as large as they do, what other medication varies in dosage as much?
nerdsniper
5 hours ago
Vitamin B12 supplements can be found in a range covering about 4 orders of magnitude. The RDA is 2.4 ug/day and the Costco daily multivitamin provides 6mcg, but here is someone selling 10,000 ug supplements: https://www.hartzells.com/b-12-10000mcg-90960
It's easy to find any other order of magnitude between those if you like. A half-pound of beef liver would give you about 186 ug.
muvlon
7 hours ago
They're supplements, not medication, but I've seen crazy variation in the dosages of Vitamin D pills.
whycome
7 hours ago
2000iu….or 60000iu. Yep.
tpm
7 hours ago
I suspect the dosage and absorption isn't fully understood yet or very individual. For me some 2mg pills work fine and other 3mg pills don't; currently I use 4mg time-release and it's mostly fine. 1 mg is definitely not enough for me.
I would be groggy a few hours after taking the pill but not in the morning.
ohthehugemanate
7 hours ago
Since they're not regulated as medication, melatonin pills have no guarantees about actual melatonin content. In studies, the vast majority of supplement labels are inaccurate.
ButlerianJihad
6 hours ago
Remember the NIST reference samples...?
https://store.usp.org/product/1380105?srsltid=AfmBOop0oZFH9S...
HexPhantom
7 hours ago
Seriously, separating the 2mg and 5mg groups would make this a lot more informative
gojomo
3 hours ago
And having a 0.3mg (300mcg) group - the dose many meticulous online self-experimenters have found sufficient, a mere 15% of their lowest-tested 2mg.
Would a headline "morning coffee found to cause stomach problems and anxiety" be reasonable, if the smallest dose tested was 7 cups – and that dosage fact was omitted from the attached abstract/story?
turtleyacht
9 hours ago
Coffee isn't mentioned. Morning cognition could be impacted by whether subjects take caffeine before starting tasks.
HexPhantom
7 hours ago
Good point. For regular coffee drinkers, testing an hour after waking without their usual caffeine could be its own cognitive impairment experiment
lostlogin
6 hours ago
It’s hard to do a blind test on yourself.
But I accidentally ran this test on myself recently and didn’t realise until I got home and found my full cup on the bench.
It was disturbing to know how much I need it.
epihelix
2 hours ago
As someone who (foolishly) only drank decaf until my early 40s, I can tell you that the mental difference when you start drinking caffeine is just amazing.
It is wonderful stuff. And not only can you finally think in the mornings, but provided you don't get heart issues from it, it appears to reduce your risk of Alzheimer's substantially.
znpy
8 hours ago
Indeed the best melatonin supplement i took was a small spray bottle where each hit was 500mg
layer8
3 hours ago
I hope you mean µg.
DANmode
9 hours ago
5 is almost universally too much.
4 is almost universally too much..
3 is the most I’ve ever recommended.
More than enough.
kylecazar
3 hours ago
I take a 3mg every night, but I've read that independent labs have studied the common OTC brands and found wildly different Melatonin content than advertised.
So I really don't know how much I take.
pazimzadeh
7 hours ago
less than 1 is plenty
alfiedotwtf
5 hours ago
5 as in milligrams?! I’ve found 10mg is sometimes just enough, but 20-30mg is where I actually feel a noticeable difference
bardsore
3 hours ago
That is an extreme amount