>It has been ingrained in culture and personal experience that weight loss is supposed to be a struggle.

The social stigma against "the easy way out" is probably due to the romanticization of self-improvement. You're "supposed to" earn a good-looking body through hard work and dedication; the journey is supposed to reflect the desire to improve and a strong mindset and thus it is seen as valuable. For many, is something really self-improvement if there is no improvement on the inside?

I think weight loss drugs will be like plastic surgery; the pipeline from medicine to undesireable modification to commonplace acceptance will likely occur. These cosmetic procedures will become accepted and become our new normal. Perhaps, in the not-so-far future, weight-loss drugs will be as common as braces.