A weirdly low-information article.

If anybody's curious, the drug is called AD109. It combines "an antimuscarinic, aroxybutynin (2.5 mg), with a selective norepinephrine reuptake inhibitor, atomoxetine (75 mg)." https://www.sciencedirect.com/science/article/pii/S245186542...

Atomoxetine is an old generic.

Aroxybutynin is (R)-Oxybutynin. Oxybutynin is an ancient (>50 year old) generic. Wikipedia notes that "the (R)-enantiomer is a more potent anticholinergic than either the racemate or the (S)-enantiomer, which is essentially without anticholinergic activity at doses used in clinical practice. However, (R)-oxybutynin administered alone offers little or no clinical benefit above and beyond the racemic mixture."

If you have sleep apnea and live in a country where you can buy most drugs OTC, this "Holy Grail" is something you can put together for yourself by tomorrow! Simply combine oxybutynin 5mg with atomoxetine 75mg, and done.

> In very simplified terms, the medication works by waking up the brain stem, preventing full muscle relaxation in the throat, while allowing the brain itself to rest during sleep.

I wonder if this is the same level of restorative rest one would get without keeping the brain stem awake?

The purple sleep pills at Walmart work pretty good, but you might have to take 2+.

I’ve tried melatonin and magnesium and they never helped

> (CPAP machines) it’s hated by most everyone who has to use it. Many people with sleep apnea refuse to try it or won’t even get diagnosed for fear they may have to.

After knowing I've had sleep apnea for the past 10 years, I actually want the damn machine... I'm sick of having to sleep 3-4 times a day and still feeling like trash.