There are other wise sayings in the Orange Catholic Bible: https://dune.fandom.com/wiki/Orange_Catholic_Bible

This particular quote comes humanity's struggles through the Butlerian Jihad: https://dune.fandom.com/wiki/Butlerian_Jihad

The problem is, if you combine ability with possibility, then it is bound to happen.

Punished for building a tower, now the builders are machines.

Someone smacked the hornet's nest

Yes we can!

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