ggm
14 hours ago
In cell cultures. So nothing about topical, or digestive pathways. Just, expose cells to vitamin c rich medium.
How would topical application work, and what kind of homeostasis effect, from ingestion.
If you are low on vitamin c in your diet, sure. If not, you may not get much benefit from having more.
ethan_smith
11 hours ago
Topical vitamin C (L-ascorbic acid) at concentrations of 10-20% with pH <3.5 can penetrate the stratum corneum, though stability and formulation significantly impact bioavailability.
jijijijij
2 hours ago
You can just freshly mix cheap vitamin C powder and water to the desired concentration, adjust pH to be less irritating. The solution can last for a few days, if cooled and protected from light. For it to be effective (according to studies), it needs to be applied daily/frequently. However, DIY is so cheap, you can use it all over your body. Wash/wipe off excess (see below).
The problem is commercialization. Vitamin C is very, very reactive, so formulating it for shelf storage and production is challenging. I think you either have to add expensive/exotic antioxidant systems, or rely on ascorbate derivatives which may be less/not effective.
Fair warning: Vitamin C degrades to dehydroascorbic acid: After some delay, vitamin C solution may stain skin and everything in contact yellow. DHA may also further break down into erythrulose, a self-tanning agent browning the skin semi-permanently (likely not very healthy). Vitamin C may also react with other things (eg. skin care products) in unpredictable ways and can actually form radicals under some conditions. Eg. It can react with benzoic acid to form benzene. On the modern skin, with UV exposure, a primordial soup of "actives", complex hydrocarbons and all natural metal catalysts, vitamin C may facilitate genesis…
The science is promising, but the chemistry of vitamin C is hard to control, or even reason about.
inkyoto
2 hours ago
> The problem is commercialization. Vitamin C is very, very reactive.
… hence it oxidises easily.
There has recently been a novel development, ethyl ascorbic acid, that is much more stable due to being more inert. It resists the oxidation for a much longer time compared to ascorbyl glucoside and L-ascorbic acid, and it has been successfully commercialised in some skincare products. The products using it command a premium, though.
jijijijij
an hour ago
AFAIK, the derivatives are less researched, so hard to argue about. Often, the concentration isn’t disclosed, too.
I would just go DIY, since commercial products are either very, very expensive, or ineffective. Once you got your measurements down, mixing it freshly takes no time. And you can afford to use it all over the body, not just the face. This way you know, it’s not oxidized, it’s exactly what’s used in some better studies, it is effective. Even DIYing a stabilized formulation with ferulic acid is possible and still much cheaper.
Personally, I have trust issues with vitamin C chemistry tho :D
cookiengineer
5 hours ago
Maybe plasters with ascorbin acid in it? That would be the first thing that comes to mind. Or maybe plaster spray where it's mixed with the typical protein foam?
majkinetor
7 hours ago
Everybody is low on C in diet. It's thermolabile, and there is glucose competition for GLUT transporters.
IMO, everybody should take at least 2g daily in a couple of doses, particularly smokers.
nabla9
4 hours ago
This is not true. 2g is the max recommended dose.
Most people can get enough vitamin C each day from food or drink. 3/4 cup of orange juice daily is enough. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-h...
Taking vitamin C orally decreases muscle mitochondrial biogenesis and harms the health benefits of training, like increased insulin resistance. (well established from multiple studies, easy to google).
There was huge antioxidant craze in late 90's and 00's when taking antioxidant supplements like C was considered the right thing to do. Now we know that just taking more antioxidants does not directly help with oxidization tress, because it messes up metabolism and can even increase it.
bryant
3 hours ago
For those who don't want to Google:
• https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/jphy...
majkinetor
2 hours ago
Cherry picking 2 studies out of zillions and calling it science? Good job
nabla9
2 hours ago
> well established from multiple studies, easy to google
That's not all of them. You can find systematic reviews and meta-analyses walking trough them all. Easy to google. 50-100 mg per day is OK and possible has some benefits, if you go to more than 2 grams like you suggested for health person, there is no evidence of benefits, only harms.
majkinetor
an hour ago
There are literary thousands of papers on C every year, basically all are positive.
Animals make it in grams, all of them on this planet. Yet you claim 50mg is only OK.
Get serious.
majkinetor
2 hours ago
Yeah, you go with orange juice, you seem to know this topic :)
nabla9
an hour ago
I now enough that your > 2g is bogs claim.
majkinetor
an hour ago
Yeah, me and Pauling, double time Nobel winner and the only one in history :)
jb1991
2 hours ago
Please do not spread misinformation here. It can be misleading at best, dangerous at worst.
majkinetor
43 minutes ago
Please don't spread fear here, vitamin C is non-toxic and can only help people, and this place represents a hacking oriented culture.
Find me a case report about the danger of vitamin C (not a theoretical one) and we can talk. Otherwise, you are free to behave and believe in whatever you want.